Process for preventing diarrhea in animals

ABSTRACT

There is disclosed a pharmaceutical composition for animals comprising at least one of a vinegar, a flesh of Japanese apricot, oranges, tomatoes and strawberries; and saccharides or a combination of saccharides and an edible organic acid, and optionally containing Lactobacillus bifidus.

This application is a continuation of application Ser. No. 539,629,filed Jun. 18, 1990, which is a continuation-in-part of Ser. No.463,003, filed Jan. 8, 1990, which is a continuation of Ser. No.142,914, filed Jan. 12, 1988, all now abandoned.

FIELD OF THE INVENTION

This invention relates to a pharmaceutical composition for animalsexcluding humans which is used alone or in admixture with water or witha feed stuff.

BACKGROUND OF THE INVENTION

In the breeding of animals, there are problems such as the frequentoccurrence of diarrhea and other diseases. In general, there has beensupplied to animals an antibiotic or a feed stuff containing anantibiotic to avoid those diseases. However, in such cases, it has beenfairly difficult to prevent such diseases. Further, the application of alarge quantity of the antibiotics to animals causes the remaining of theantibiotics in the body, eggs, milk and the like of animals. Theremaining antibiotics bring harmful influences on people who take meats,eggs and milk containing the antibiotics to produce sometimes anti-drugsbacilli in the bodies of the people.

Now, we have found a safe pharmaceutical composition for animals whichis based on natural materials and can prevent the frequent occurrence ofdiarrhea and other diseases of animals.

Therefore, it is an object of the present invention to provide apharmaceutical composition for animals which is based on safe naturalmaterials and which can step up the growth of the animals by theprevention of the frequent occurrence of diarrhea and other diseases ofanimals. A further object is to provide a pharmaceutical compositionfavored by animals. Another object is to provide a pharmaceuticalcomposition for animals being safe for people who take meats, eggs andmilks of the animals.

SUMMARY OF THE INVENTION

The present invention relates to a pharmaceutical composition foranimals excluding humans comprising:

(A) at least one of a vinegar, a flesh of Japanese apricot (umeapricot), oranges and strawberries, and

(B) (i) saccharides or (ii) a combination of saccharides and an edibleorganic acid.

Further, the present invention relates to a pharmaceutical compositionfor animals excluding humans comprising:

(A) at least one of a vinegar, a flesh of Japanese apricot (umeapricot), oranges and strawberries,

(B) (i) saccharides or (ii) a combination of saccharides and an edibleorganic acid, and

(C) Lactobacillus bifidus.

Still further, the present invention relates to a method of supplyingsaid pharmaceutical compositions to animals.

In addition, the present invention relates to a feed stuff for animalscontaining said pharmaceutical compositions.

DETAILED DESCRIPTION

The pharmaceutical composition of the present invention may be fed toanimals excluding humans such as domestic animals, e.g. cattle, horse,pig, sheep, goat and the like; poultries, e.g. hen, cock, chicken,turkey, duck, guinea fowl, quail and the like; pets, e.g. dog, cat andthe like; fishes, e.g. yellowtail, horse mackerel, flat fish, sea bream,red sea bream, eel, carp, rainbow trout, sweet fish, tilapia and thelike.

In the present invention, both of a fermented vinegar and a synthesizedvinegar may be used as the vinegar in component (A). A fermentedvinegar, which includes rice vinegar, malt vinegar, alcohol vinegar,cider vinegar, wine vinegar or the like, is preferable. Both of liquidand solid vinegars may be used. A powdery vinegar is more preferable inthe view point of easy handling and easy feeding to animals and thelike.

The flesh of Japanese apricot used in said component (A) may be used inthe smashed form or in the form of powder. Extractives from the flesh ofJapanese apricot also may be used. The flesh of Japanese apricot may beone previously salted or dipped in alcohol. The raw flesh of Japaneseapricot also may be used. However, when the raw flesh of Japaneseapricot is used, it should be avoided that the raw flesh is contaminatedwith hydrocyanic acid contained in the stone of the raw Japaneseapricot.

The oranges, tomatoes and strawberries may be used in the form ofsmashed form, powder, juice and the like. Further, a powdery rind oforanges may be used. As the oranges, there may be used lemons, satsumamandarins, oranges, citron fruits and the like.

The vinegars, flesh of Japanese apricot, oranges, tomatoes andstrawberries may be used alone or in admixture of two or more of them.They provide the pharmaceutical composition of the present inventionwith a good taste to make the animals take the composition readily.Especially, vinegars and the flesh of the Japanese apricot arepreferable, and they may be used alone or in combination of them.

In the present invention, as the saccharides in said component (B),there may be used sugar, glucose, lactose, fruit sugar and the like,which may be used alone or in combination of them. Especially, sugar andglucose are preferable in view of the animal's favorite.

As edible organic acid in said component (B), any of animal-edibleorganic acids may be used. As examples of them, there may be usedcarboxylic acids such as citric acid, malic acid, fumaric acid, formicacid, succinic acid, tartaric acid, lactic acid and the like, which maybe used alone or in combination of them. Among them, citric acid,fumaric acid and lactic aid are more preferable in the view points ofthe prevention of diarrhea and other diseases of animals and animal'sfavorite.

Some of those carboxylic acids are the same as carboxylic acids includedin said vinegars, flesh of Japanese apricot, oranges, tomatoes andstrawberries used as component (A) in the present invention. However,said "edible organic acid" used as component (B) in the presentinvention means a refined organic acid and is added into the feedcomposition of the present invention independently of said component(A). As said component (B), saccharides may be used alone or inadmixture with the edible organic acid.

The occurrence of diseases of animals is more effectively prevented bythe addition of Lactobacillus bifidus to the pharmaceutical compositioncomprising said components (A) and (B). Both of dried and undriedLactobacillus bifidus may be used.

In the present invention, a mix proportion of each component may varydepending on animal's kind, age, body weight and the like. In general,the pharmaceutical composition of the present invention comprises about0.1-50% by weight of the component (A) and about 99.9-50% by weight ofcomponent (B). When mixtures of saccharides and the edible organic acidare used as the component (B) in the present invention, thepharmaceutical composition of the present invention comprises about0.1-50% of at least one of the vinegar, flesh of Japanese apricot,oranges, tomatoes and strawberries, about 10-99.9% of the saccharidesand about 1-60% of the edible organic acid based on the total weight ofthe pharmaceutical composition. When Lactobacillus bifidus is furtheradded, in general, it is added in amounts of about 2.5×10⁶⁻⁸ cells per100 g of a dry basis of the components (A) and (B).

The preferable embodiments of the present invention are as follows:

In the following embodiments, "%" is based on the total weight of thecomposition.

(1) A pharmaceutical composition comprising 1-25% of the vinegar, 1-20%of the flesh of Japanese apricot, 15-95.5% of saccharide and 2.5-40% ofthe edible organic acid.

(2) A pharmaceutical composition comprising 1-25% of the vinegar and75-99% of saccharides.

(3) A pharmaceutical composition comprising 1-20% of the flesh of theJapanese apricot and 80-99% of saccharides. (4) A pharmaceuticalcomposition comprising 1-25% of the vinegar, 1-20% of the flesh ofJapanese apricot and 55-98% of saccharides.

(5) A pharmaceutical composition comprising 1-25% of the vinegar, 1-20%of the flesh of Japanese apricot, 15-95.5% of saccharide and 2.5-40% ofthe edible organic acid and 2.5×10⁸⁻¹⁰ cells of the Lactobacillusbifidus per 100 g on a dry basis of the vinegar, flesh of Japaneseapricot, saccharides and edible organic acid.

(6) A pharmaceutical composition comprising 1-25% of the vinegar,35-96.5% of saccharides and 2.5-40% of the edible organic acid and2.5×10⁸⁻¹⁰ cells of the Lactobacillus bifidus per 100 g on a dry basisof the vinegar, saccharides and edible organic acid.

(7) A pharmaceutical composition comprising 1-20% of the flesh ofJapanese apricot. 40-96.5% of saccharides and 2.5-40% of the edibleorganic acid and 2.5×10⁸⁻¹⁰ cells of the Lactobacillus bifidus per 100 gon a dry basis of the flesh of Japanese apricot, saccharides and edibleorganic acid.

Each component element is mixed according to any conventional methods.

The pharmaceutical composition for animals of the present invention maybe solely fed to animals excluding humans. However, the pharmaceuticalcomposition is more preferably fed to animals in the form of a solutionor dispersion in water, or in admixture with a base feed stuff such ascorns, wheat bran, wheat, wheat flour, soybean meal, milo, fish meal,fish powder, their mixture or the like. In such cases, about 0.1-10% ofthe pharmaceutical composition is generally added to water or the basefeed stuff based on the weight of water or the feed stuff.

Further, the pharmaceutical composition may previously be mixed with thefeed stuff.

In general, the pharmaceutical composition of the invention is fed toanimals in the amount of about 0.01-10 g per 1 kg of the body weight ofthe animal. However, the amount may be varied.

Further, the pharmaceutical composition of the invention may be used inadmixture with other therapeutic agents.

The pharmaceutical composition for animals of the invention can preventmore effectively the frequent occurrence of diarrhea, loose feces andother diseases than a composition consisting of saccharides and anedible organic acid. As the result, the pharmaceutical composition ofthe present invention can step up the growth of the animals.

The pharmaceutical composition of the present invention is based on onlysafe natural materials and thus is safe to animals and people who takemeats, eggs, milk and the like of the animals, and animals take itfavorably. The animals which take the pharmaceutical composition of thepresent invention provide us with good meats. When the pharmaceuticalcomposition of the present invention is fed to cows, the production ofmilk increases, and the proportion of the milk fat in milk increases.

Further, the present pharmaceutical composition for animals can be fedto animals in admixture with other therapeutic agents.

The present invention described herein is illustrated by the followingexamples. These examples do not limit the present invention.

In the following examples, "Mean Mil Fat percentage" (called hereinafter"M.M.F. %"), "Proportion of Grown Animals" (called hereinafter"P.G.A."), "Increased Body Weight/animal·day" (called hereinafter"I.W./a.d.") and "Ingestion amount/animal·day" (called hereinafter"Ingestion") are calculated according to the following equations.##EQU1##

In the following examples, a powdery rice vinegar (Mitsukansu Co.) wasused as the vinegar, and a powdery flesh of Japanese apricot produced byIkeda Touka Co. was used as the flesh of Japanese apricot, and powderyrind of lemon (Nankaikako Co.) was used as the lemon powder, and tomatopowder produced by Spreader Co. was used as the tomato powder, and driedLactobacillus bifidus (Oriental Koubo Co.) was used as the Lactobacillusbifidus.

EXAMPLES 1-94 AND COMPARATIVE EXAMPLES 1-38

Components shown in Table 1 below ere mixed in accordance with weightproportions shown in Table 1 to prepare pharmaceutical compositions foranimals of the present Examples 1-94 and Comparative Examples 1-38.

Each pharmaceutical composition was diluted with water by way of a givenmagnification shown in Table 1, and then fed freely to animals insteadof water. After a given test period, the total number of animalssuffering from diarrhea and loose feces (called hereinafter "total D &L") was counted. The results are shown in Table 1 below.

                                      TABLE 1-(i)                                 __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)                  Results                                   Powdery flesh                                                                         Lactobacillus                                                                        Kind  Number                                                                             Feed      Total D&L/                       Citric   of Japanese                                                                           bifidus                                                                              of    of   periods                                                                           Dilution                                                                            total number                 Sugar                                                                             acid                                                                              Vinegar                                                                            apricot (cells/100 g)                                                                        animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of                    __________________________________________________________________________                                                            animals               Example                                                                        1     90  7.5 2.5                 Pig (4                                                                              10   21  25    42/210                                                   weeks old)                                  2     91.25                                                                             7.5      1.25           Pig (4                                                                              10   21  25    40/210                                                   weeks old)                                  3     88.75                                                                             7.5 2.5  1.25           Pig (4                                                                              10   21  25    20/210                                                   weeks old)                                  4     90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                              10   21  25    30/210                                                   weeks old)                                  5     91.25                                                                             7.5      1.25    2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                              10   21  25    31/210                                                   weeks old)                                  6-A   88.75                                                                             7.5 2.5  1.25    2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                              10   21  25    15/210                                                   weeks old)                                  6-B   92.5    7.5                 Pig (4                                                                              10   21  25    41/210                                                   weeks old)                                  6-C   92.5         7.5     2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                              10   21  25    40/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        1     92.5                                                                              7.5                     Pig (4                                                                              10   21  25    71/210                                                   weeks old)                                 Example                                                                        7     96.9                                                                              3   0.1                 Pig (4                                                                              10   21  25    60/210                                                   weeks old)                                  8     96.9                                                                              3        0.1            Pig (4                                                                              10   21  25    67/210                                                   weeks old)                                  9     96.8                                                                              3   0.1  0.1            Pig (4                                                                              10   21  25    50/210                                                   weeks old)                                 10     96.9                                                                              3   0.1          2.5 × 10.sup.6 /100 g                                                          Pig (4                                                                              10   21  25    52/210                                                   weeks old)                                 11     96.9                                                                              3        0.1     2.5 × 10.sup.6 /100 g                                                          Pig (4                                                                              10   21  25    53/210                                                   weeks old)                                 12-A   96.8                                                                              3   0.1  0.1     2.5 × 10.sup.6 /100 g                                                          Pig (4                                                                              10   21  25    45/210                                                   weeks old)                                 12-B   97      3            2.5 × 10.sup.6 /100 g                                                          Pig (4                                                                              10   21  25    59/210                                                   weeks old)                                 12-C   97           3              Pig (4                                                                              10   21  25    60/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        2     97  3                       Pig (4                                                                              10   21  25    75/210                                                   weeks old)                                 Example                                                                       13     40  25  15   20             Pig (4                                                                              10   21  25    30/210                                                   weeks old)                                 14     55  25       20                   10   21  25    31/210                15     40  25  15   20             Pig (4                                                                              10   21  25    12/210                                                   weeks old)                                 16     60  25  15           2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                              10   21  25    22/210                                                   weeks old)                                 17     55  25       20      2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                              10   21  25    21/210                                                   weeks old)                                 18-A   40  25  15   20      2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                              10   21  25     8/210                                                   weeks old)                                 18-B   75      25                  Pig (4                                                                              10   21  25    29/210                                                   weeks old)                                 18-C   75      5    20      2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                              10   21  25    31/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        3     75  25                      Pig (4                                                                              10   21  25    60/210                                                   weeks old)                                 Example                                                                       19     90  7.5 2.5                 Calf (2                                                                             10   21  25    50/210                                                   weeks old)                                 20     91.25                                                                             7.5      1.25           Calf (2                                                                             10   21  25    49/210                                                   weeks old)                                 21     88.75                                                                             7.5 2.5  1.25           Calf (2                                                                             10   21  25    25/210                                                   weeks old)                                 22-A   90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Calf (2                                                                             10   21  25    32/210                                                   weeks old)                                 22-B   92.5    7.5          2.5 × 10.sup.8 /100 g                                                          Calf (2                                                                             10   21  25    48/210                                                   weeks old)                                 22-C   92.5         7.5            Calf (2                                                                             10   21  25    50/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        4     92.5                                                                              7.5                     Calf (2                                                                             10   21  25    108/210                                                  weeks old)                                 Example                                                                       23     96.9                                                                              3   0.1                 Calf (2                                                                             10   21  25    60/210                                                   weeks old)                                 24     96.9                                                                              3        0.1            Calf (2                                                                             10   21  25    56/210                                                   weeks old)                                 25     96.8                                                                              3   0.1  0.1            Calf (2                                                                             10   21  25    34/210                                                   weeks old)                                 26-A   96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Calf (2                                                                             10   21  25    40/210                                                   weeks old)                                 26-B   97      3                   Calf (2                                                                             10   21  25    57/210                                                   weeks old)                                 26-C   97           3       2.5 × 10.sup.8 /100 g                                                          Calf (2                                                                             10   21  25    59/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        5     97  3                       Calf (2                                                                             10   21  25    98/210                                                   weeks old)                                 Example                                                                       27     40  25  15   20             Calf (2                                                                             10   21  100   60/210                                                   weeks old)                                 28-A   60  25  15           2.5 × 10.sup.10 /100 g                                                         Calf (2                                                                             10   21  100   44/210                                                   weeks old)                                 28-B   75      25           2.5 × 10.sup.10 /100 g                                                         Calf (2                                                                             10   21  100   61/210                                                   weeks old)                                 28-C   75      5    20             Calf (2                                                                             10   21  100   58/210                                                   weeks old)                                 Comparative                                                                   Example                                                                        6     75  25                      Calf (2                                                                             10   21  100   101/210                                                  weeks old)                                 Example                                                                       29     90  7.5 2.5                 Lamb (4                                                                             10   28  25    22/280                                                   weeks old)                                 30     91.25                                                                             7.5      1.25           Lamb (4                                                                             10   28  25    20/280                                                   weeks old)                                 31     88.75                                                                             7.5 2.5  1.25           Lamb (4                                                                             10   28  25    10/280                                                   weeks old)                                 32-A   90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Lamb (4                                                                             10   28  25    15/280                                                   weeks old)                                 32-B   92.5    7.5                 Lamb (4                                                                             10   28  25    23/280                                                   weeks old)                                 32-C   92.5         7.5     2.5 × 10.sup.8 /100 g                                                          Lamb (4                                                                             10   28  25    20/280                                                   weeks old)                                 Comparative                                                                   Example                                                                        7     92.5                                                                              7.5                     Lamb (4                                                                             10   28  25    62/280                                                   weeks old)                                 Example                                                                       33     96.9                                                                              3   0.1                 Lamb (4                                                                             10   28  25    32/280                                                   weeks old)                                 34     96.9                                                                              3        0.1            Lamb (4                                                                             10   28  25    30/280                                                   weeks old)                                 35     96.8                                                                              3   0.1  0.1            Lamb (4                                                                             10   28  25    20/280                                                   weeks old)                                 36-A   96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Lamb (4                                                                             10   28  25    29/280                                                   weeks old)                                 36-B   97      3            2.5 × 10.sup.8 /100 g                                                          Lamb (4                                                                             10   28  25    31/280                                                   weeks old)                                 36-C   97           3              Lamb (4                                                                             10   28  25    33/280                                                   weeks old)                                 Comparative                                                                   Example                                                                        8     97.0                                                                              3                       Lamb (4                                                                             10   28  25    60/280                                                   weeks old)                                 Example                                                                       37     40  25  15   20             Lamb (4                                                                             10   28  100   40/280                                                   weeks old)                                 38-A   60  25  15           2.5 × 10.sup.10 /100 g                                                         Lamb (4                                                                             10   28  100   36/280                                                   weeks old)                                 38-B   75      25                  Lamb (4                                                                             10   28  100   38/280                                                   weeks old)                                 38-C   75      5    20      2.5 × 10.sup.10 /100 g                                                         Lamb (4                                                                             10   28  100   40/280                                                   weeks old)                                 Comparative                                                                   Example                                                                        9     75  25                      Lamb (4                                                                             10   28  100   61/280                                                   weeks old)                                 Example                                                                       39     90  7.5 2.5                 Chicken (3                                                                          200  35  25    423/7000                                                 weeks old)                                 40     91.25                                                                             7.5      1.25           Chicken (3                                                                          200  35  25    403/7000                                                 weeks old)                                 41     88.75                                                                             7.5 2.5  1.25           Chicken (3                                                                          200  35  25    198/7000                                                 weeks old)                                 42-A   90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Chicken (3                                                                          200  35  25    309/7000                                                 weeks old)                                 42-B   92.5    7.5          2.5 × 10.sup.8 /100 g                                                          Chicken (3                                                                          200  35  25    403/7000                                                 weeks old)                                 42-C   92.5         7.5            Chicken (3                                                                          200  35  25    394/7000                                                 weeks old)                                 Comparative                                                                   Example                                                                       10     92.5                                                                              7.5                     Chicken (3                                                                          200  35  25    1066/7000                                                weeks old)                                 Example                                                                       43     96.9                                                                              3   0.1                 Chicken (3                                                                          200  35  25    603/7000                                                 weeks old)                                 44     96.9                                                                              3   0.1                 Chicken (3                                                                          200  35  25    600/7000                                                 weeks old)                                 45     96.8                                                                              3   0.1  0.1            Chicken (3                                                                          200  35  25    503/7000                                                 weeks old)                                 46-A   96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Chicken (3                                                                          200  35  25    621/7000                                                 weeks old)                                 46-B   97      3                   Chicken (3                                                                          200  35  25    634/7000                                                 weeks old)                                 46-C   97           3       2.5 × 10.sup.8 /100 g                                                          Chicken (3                                                                          200  35  25    611/7000                                                 weeks old)                                 Comparative                                                                   Example                                                                       11     97.0                                                                              3                       Chicken (3                                                                          200  35  25    1050/7000                                                weeks old)                                 Example                                                                       47     40  25  15   20             Chicken (3                                                                          200  35  100   611/7000                                                 weeks old)                                 48-A   60  25  15           2.5 × 10.sup.10 /100 g                                                         Chicken (3                                                                          200  35  100   601/7000                                                 weeks old)                                 48-B   75      25           2.5 × 10.sup.10 /100 g                                                         Chicken (3                                                                          200  35  100   641/7000                                                 weeks old)                                 48-C   75      24   1              Chicken (3                                                                          200  35  100   636/7000                                                 weeks old)                                 Comparative                                                                   Example                                                                       12     75  25                      Chicken (3                                                                          200  35  100   1023/7000                                                weeks old)                                 Example                                                                       49     90  7.5 2.5                 Dog (65                                                                             20   35  25    40/700                                                   days old)                                  50     91.25                                                                             7.5      1.25           Dog (65                                                                             20   35  25    45/700                                                   days old)                                  51     88.75                                                                             7.5 2.5  1.25           Dog (65                                                                             20   35  25    25/700                                                   days old)                                  52-A   90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Dog (65                                                                             20   35  25    36/700                                                   days old)                                  52-B   92.5    7.5                 Dog (65                                                                             20   35  25    41/700                                                   days old)                                  52-C   92.5         7.5     2.5 × 10.sup.8 /100 g                                                          Dog (65                                                                             20   35  25    50/700                                                   days old)                                  Comparative                                                                   Example                                                                       13     92.5                                                                              7.5                     Dog (65                                                                             20   35  25    141/700                                                  days old)                                  Example                                                                       53     96.9                                                                              3   0.1                 Dog (65                                                                             20   35  25    62/700                                                   days old)                                  54     96.9                                                                              3        0.1            Dog (65                                                                             20   35  25    64/700                                                   days old)                                  55     96.8                                                                              3   0.1  0.1            Dog (65                                                                             20   35  25    50/700                                                   days old)                                  56-A   96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Dog (65                                                                             20   35  25    50/700                                                   days old)                                  56-B   97      3            2.5 × 10.sup.8 /100 g                                                          Dog (65                                                                             20   35  25    66/700                                                   days old)                                  56-C   97           3              Dog (65                                                                             20   35  25    58/700                                                   days old)                                  Comparative                                                                   Example                                                                       14     97  3                       Dog (65                                                                             20   35  25    120/700                                                  days old)                                  Example                                                                       57     40  25  15   20             Dog (65                                                                             20   35  100   70/700                                                   days old)                                  58-A   60  25  15           2.5 × 10.sup.10 /100 g                                                         Dog (65                                                                             20   35  100   72/700                                                   days old)                                  58-B   75      5    20             Dog (65                                                                             20   35  100   60/700                                                   days old)                                  58-C   75      24   1       2.5 × 10.sup.10 /100 g                                                         Dog (65                                                                             20   35  100   65/700                                                   days old)                                  Comparative                                                                   Example                                                                       15     75  25                      Dog (65                                                                             20   35  100   112/700                                                  days old)                                  Example                                                                       59     10  50  30   10             Dog (65                                                                             20   35  100   62/700                                                   days old)                                  60     10  50  15   25             Dog (65                                                                             20   35  100   59/700                                                   days old)                                  61-A   88  1   1    10             Dog (65                                                                             20   35  100   56/700                                                   days old)                                  61-B   99      1                   Dog (65                                                                             20   35  100   60/700                                                   days old)                                  61-C   99           1              Dog (65                                                                             20   35  100   63/700                                                   days old)                                  Comparative                                                                   Example                                                                       16     10  90                      Dog (65                                                                             20   35  100   116/700                                                  days old)                                  17     50  50                      Dog (65                                                                             20   35  100   109/700                                                  days old)                                  18     99  1                       Dog (65                                                                             20   35  100   113/700                                                  days old)                                  __________________________________________________________________________     (*) Water dilution magnification (times)                                 

                                      TABLE 1-(ii)                                __________________________________________________________________________           Mix proportions of each component in pharma-                                  ceutical composition for animals (wt. %)    Results                                            Powdery                                                                             Kind  Number                                                                             Feed      Total D&L/                              Lactic     rind of                                                                             of    of   periods                                                                           Dilution (*)                                                                        total number                      Glucose                                                                             acid Vinegar                                                                             lemon animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of animals                 __________________________________________________________________________    Example                                                                       62     10    50   30    10    Dog (65                                                                             20   35  100   60/700                                                   days old)                                       63     10    50   15    25    Dog (65                                                                             20   35  100   58/700                                                   days old)                                       64     88    1    1     10    Dog (65                                                                             20   35  100   61/700                                                   days old)                                       65     98.9  1          0.1   Dog (65                                                                             20   35  100   57/700                                                   days old)                                       66-A   88.75 7.5  2.5   1.25  Dog (65                                                                             20   35  100   40/700                                                   days old)                                       66-B   92.5       2.5   5     Dog (65                                                                             20   35  100   61/700                                                   days old)                                       66-C*  92.5                   Dog (65                                                                             20   35  100   64/700                                                   days old)                                       Comparative                                                                   Example                                                                       19     10    90               Dog (65                                                                             20   35  100   100/700                                                  days old)                                       20     50    50               Dog (65                                                                             20   35  100   110/700                                                  days old)                                       21     99    1                Dog (65                                                                             20   35  100   108/700                                                  days old)                                       22     92.5  7.5              Dog (65                                                                             20   35  100   110/700                                                  days old)                                       __________________________________________________________________________     (*) Water dilution magnification (times)                                      *In addition to glucose, 2.5 wt. % of powdery flesh of Japanese apricot       and 50 wt. % of powdery tomato are mixed.                                

                                      TABLE 1-(iii)                               __________________________________________________________________________           Mix proportions of each component in pharma-                                                                              Results                           ceutical composition for animals (wt. %)                                                             Kind  Number                                                                             Feed      Total D&L/                              Fumaric    Powdery                                                                             of    of   periods                                                                           Dilution (*)                                                                        total number                      Glucose                                                                             acid Vinegar                                                                             tomato                                                                              animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of animals                 __________________________________________________________________________    Example                                                                       67     10    50   30    10    Dog (65                                                                             20   35  100   61/700                                                   days old)                                       68     10    50   15    25    Dog (65                                                                             20   35  100   63/700                                                   days old)                                       69     88    1    1     10    Dog (65                                                                             20   35  100   60/700                                                   days old)                                       70     98.9  1          0.1   Dog (65                                                                             20   35  100   58/700                                                   days old)                                       71-A   88.75 7.5  2.5   1.25  Dog (65                                                                             20   35  100   38/700                                                   days old)                                       71-B*.sup.2                                                                          99                     Dog (65                                                                             20   35  100   60/700                                                   days old)                                       71-C   99               1     Dog (65                                                                             20   35  100   59/700                                                   days old)                                       Comparative                                                                   Example                                                                       23     10    90               Dog (65                                                                             20   35  100   101/700                                                  days old)                                       24     50    50               Dog (65                                                                             20   35  100   105/700                                                  days old)                                       25     99    1                Dog (65                                                                             20   35  100   109/700                                                  days old)                                       __________________________________________________________________________     (*) Water dilution magnification (times)                                      *.sup.2 In addition to 99 wt. % of glucose, 1 wt. % of powdery rind of        lemon is mixed.                                                          

                                      TABLE 1-(iv)                                __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)                  Results                                   Powdery flesh                                                                         Lactobacillus                                                                        Kind  Number                                                                             Feed      Total D&L/                       Citric   of Japanese                                                                           bifidus                                                                              of    of   periods                                                                           Dilution                                                                            total number                 Sugar                                                                             acid                                                                              Vinegar                                                                            apricot (cells/100 g)                                                                        animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of                    __________________________________________________________________________                                                            animals               Example                                                                       72     90  7.5 2.5                 Cat (60                                                                             20   35  25    21/700                                                   days old)                                  73     91.25                                                                             7.5      1.25           Cat (60                                                                             20   35  25    22/700                                                   days old)                                  74     88.75                                                                             7.5 2.5  1.25           Cat (60                                                                             20   35  25    14/700                                                   days old)                                  75-A   90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Cat (60                                                                             20   35  25    20/700                                                   days old)                                  75-B   92.5    7.5                 Cat (60                                                                             20   35  25    23/700                                                   days old)                                  75-C   92.5         7.5     2.5 × 10.sup.8 /100 g                                                          Cat (60                                                                             20   35  25    25/700                                                   days old)                                  Comparative                                                                   Example                                                                       26     92.5                                                                              7.5                     Cat (60                                                                             20   21  25    85/700                                                   days old)                                  Example                                                                       76     96.9                                                                              3   0.1                 Cat (60                                                                             20   35  25    50/700                                                   days old)                                  77     96.9                                                                              3        0.1            Cat (60                                                                             20   35  25    51/700                                                   days old)                                  78     96.8                                                                              3   0.1  0.1            Cat (60                                                                             20   35  25    40/700                                                   days old)                                  79-A   96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Cat (60                                                                             20   35  25    49/700                                                   days old)                                  79-B   97      3            2.5 × 10.sup.8 /100 g                                                          Cat (60                                                                             20   35  25    52/700                                                   days old)                                  79-C   97           3              Cat (60                                                                             20   35  25    54/700                                                   days old)                                  Comparative                                                                   Example                                                                       27     97  3                       Cat (60                                                                             20   35  25    81/700                                                   days old)                                  Example                                                                       80     40  25  15   20             Cat (60                                                                             20   35  100   47/700                                                   days old)                                  81-A   60  25  15           2.5 × 10.sup.10 /100 g                                                         Cat (60                                                                             20   35  100   44/700                                                   days old)                                  81-B   75      5    20             Cat (60                                                                             20   35  100   46/700                                                   days old)                                  81-C*.sup.3                                                                          75                   2.5 × 10.sup.10 /100 g                                                         Cat (60                                                                             20   35  100   47/700                                                   days old)                                  Comparative                                                                   Example                                                                       28     75  25                      Cat (60                                                                             20   35  100   76/700                                                   days old)                                  Example                                                                       82     10  50  30   10             Cat (60                                                                             20   35  100   50/700                                                   days old)                                  83     10  50  15   25             Cat (60                                                                             20   35  100   51/700                                                   days old)                                  84-A   88  1   1    10             Cat (60                                                                             20   35  100   48/700                                                   days old)                                  84-B   99      1                   Cat (60                                                                             20   35  100   49/700                                                   days old)                                  84-C   99           1              Cat (60                                                                             20   35  100   52/700                                                   days old)                                  Comparative                                                                   Example                                                                       29     10  90                      Cat (60                                                                             20   35  100   81/700                                                   days old)                                  30     50  50                      Cat (60                                                                             20   35  100   85/700                                                   days old)                                  31     99  1                       Cat (60                                                                             20   35  100   80/700                                                   days old)                                  __________________________________________________________________________     (*) Water dilution magnification (times)                                      *.sup.3 In addition to 75 wt. % of sugar and 2.5 × 10.sup.10 /100 g     of Lactobacillus bifidus, 5 wt. % of powdery rind of lemon and 20 wt. % o     powdery tomato are mixed.                                                

                                      TABLE 1-(v)                                 __________________________________________________________________________           Mix proportions of each component in pharma-                                  ceutical composition for animals (wt. %)    Results                                            Powdery                                                                             Kind  Number                                                                             Feed      Total D&L/                              Lactic     rind of                                                                             of    of   periods                                                                           Dilution (*)                                                                        total number                      Glucose                                                                             acid Vinegar                                                                             lemon animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of animals                 __________________________________________________________________________    Example                                                                       85     10    50   30    10    Cat (60                                                                             20   35  100   48/700                                                   days old)                                       86     10    50   15    25    Cat (60                                                                             20   35  100   47/700                                                   days old)                                       87     88    1    1     10    Cat (60                                                                             20   35  100   49/700                                                   days old)                                       88     98.9  1          0.1   Cat (60                                                                             20   35  100   48/700                                                   days old)                                       89-A   88.75 7.5  2.5   1.25  Cat (60                                                                             20   35  100   25/700                                                   days old)                                       89-B   99         1           Cat (60                                                                             20   35  100   50/700                                                   days old)                                       89-C*.sup.4                                                                          99         1           Cat (60                                                                             20   35  100   52/700                                                   days old)                                       89-D*.sup.5                                                                          92.5       5           Cat (60                                                                             20   35  100   48/700                                                   days old)                                       89-E*.sup.6                                                                          92.5             5     Cat (60                                                                             20   35  100   49/700                                                   days old)                                       Comparative                                                                   Example                                                                       32     10    90               Cat (60                                                                             20   35  100   89/700                                                   days old)                                       33     50    50               Cat (60                                                                             20   35  100   90/700                                                   days old)                                       34     99    1                Cat (60                                                                             20   35  100   88/700                                                   days old)                                       35     92.5  7.5              Cat (60                                                                             20   35  100   89/700                                                   days old)                                       __________________________________________________________________________     (*) Water dilution magnification (times)                                      *.sup.4 In addition to 99 wt. % of glucose, 1 wt. % of powdery flesh of       Japanese apricot is mixed.                                                    *.sup.5 In addition to 92.5 wt. % of glucose and 5 wt. % of vinegar, 2.5      wt. % of powdery flesh of Japanese apricot is mixed.                          *.sup.6 In addition to 92.5 wt. % of glucose and 5 wt. % of powdery rind      of lemon, 2.5 wt. % of powdery tomato is mixed.                          

                                      TABLE 1-(vi)                                __________________________________________________________________________           Mix proportions of each component in pharma-                                                                              Results                           ceutical composition for animals (wt. %)                                                             Kind  Number                                                                             Feed      Total D&L/                              Fumaric    Powdery                                                                             of    of   periods                                                                           Dilution (*)                                                                        total number                      Glucose                                                                             acid Vinegar                                                                             tomato                                                                              animal                                                                              animals                                                                            (days)                                                                            (times)                                                                             of animals                 __________________________________________________________________________    Example                                                                       90     10    50   30    10    Cat (60                                                                             20  35  100   43/700                                                    days old)                                       91     10    50   15    25    Cat (60                                                                             20  35  100   48/700                                                    days old)                                       92     88    1    1     10    Cat (60                                                                             20  35  100   49/700                                                    days old)                                       93     98.9  1          0.1   Cat (60                                                                             20  35  100   47/700                                                    days old)                                       94-A   88.75 7.5  2.5   1.25  Cat (60                                                                             20  35  100   28/700                                                    days old)                                       94-B*.sup.7                                                                          99                     Cat (60                                                                             20  35  100   51/700                                                    days old)                                       94-C   99               1     Cat (60                                                                             20  35  100   53/700                                                    days old)                                       Comparative                                                                   Example                                                                       36     10    90               Cat (60                                                                             20  35  100   90/700                                                    days old)                                       37     50    50               Cat (60                                                                             20  35  100   87/700                                                    days old)                                       38     99    1                Cat (60                                                                             20  35  100   88/700                                                    days old)                                       __________________________________________________________________________     (*) Water dilution magnification (times)                                      *.sup.7 In addition to 99 wt. % of glucose, 1 wt. % of powdery rind of        lemon is mixed.                                                          

EXAMPLES 95-114 AND COMPARATIVE EXAMPLES 39-44

Components shown in Table 2 below were mixed in accordance with weightproportions shown in Table 2 to prepare pharmaceutical compositions foranimals of the present Examples 95-114 and Comparative Examples 39-44.

Each of the pharmaceutical composition for animals was added to BaseFeed Stuff A or B shown below at a given weight proportion shown inTable 2 to prepare test feed stuffs. Each of the test feed stuffs wasfed to animals freely. "I.W./a.d." and "Ingestion" were determined. Theresults are shown in Table 2 below.

    ______________________________________                                        Composition of Base Feed Stuff A                                              ______________________________________                                        Corn              450 weight parts                                            Milo              310 weight parts                                            Soybean meal      146 weight parts                                            Rapeseed meal     30 weight parts                                             Fish powder       15 weight parts                                             Meat born meal    10 weight parts                                             Yellow grease     18 weight parts                                             Calcium carbonate  5 weight parts                                             Calcium phosphate  8 weight parts                                             Salt               3 weight parts                                             Premix vitamins & minerals                                                                       5 weight parts                                             ______________________________________                                    

    ______________________________________                                        Composition of Base Feed Stuff B                                              ______________________________________                                        Corn             300 weight parts                                             Milo             135 weight parts                                             Wheat bran        70 weight parts                                             Soybean meal     246 weight parts                                             Wheat flour      180 weight parts                                             Yellow grease     7 weight parts                                              Molasses          30 weight parts                                             Calcium carbonate                                                                              14.5 weight parts                                            Calcium triphosphate                                                                            11 weight parts                                             Salt              5 weight parts                                              Vitamins and Minerals                                                                           1.5 weight parts                                            ______________________________________                                    

                                      TABLE 2                                     __________________________________________________________________________    Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)     Num-                                                       Powdery flesh                                                                         Lactobacillus                                                                        Kind                                                                              ber Feed               In-                         Citric                                                                            Vine-                                                                             of Japanese                                                                           bifidus                                                                              of  of  periods   P.F.B.**                                                                           I.W./                                                                             gestion            Sugar    acid                                                                              gar apricot (cells/100 g)                                                                        animal                                                                            animals                                                                           (days)                                                                            K.B.F.S.*                                                                           (wt. %)                                                                            a.d.                                                                              (g)                __________________________________________________________________________    Example                                                                        95  90  7.5 2.5                Pig (4                                                                            20  14  A     2    471 500                                                weeks                                                                         old)                                           96  91.25                                                                             7.5     1.25           Pig (4                                                                            20  14  A     2    464 490                                                weeks                                                                         old)                                           97  88.75                                                                             7.5 2.5 1.25           Pig (4                                                                            20  14  A     2    468 510                                                weeks                                                                         old)                                           98-A                                                                              90  7.5 2.5         2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                            20  14  A     2    479 508                                                weeks                                                                         old)                                           98-B                                                                              92.5    7.5         2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                            20  14  A     2    469 511                                                weeks                                                                         old)                                           98-C                                                                              92.5        7.5            Pig (4                                                                            20  14  A     2    465 506                                                weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        39  92.5                                                                              7.5                    Pig (4                                                                            20  14  A     2    386 435                                                weeks                                                                         old)                                          Example                                                                        99  96.9                                                                              3   0.1                Pig (4                                                                            20  14  A     2    464 491                                                weeks                                                                         old)                                          100  96.9                                                                              3       0.1            Pig (4                                                                            20  14  A     2    450 481                                                weeks                                                                         old)                                          101  96.8                                                                              3   0.1 0.1            Pig (4                                                                            20  14  A     2    460 498                                                weeks                                                                         old)                                          102-A                                                                              96.9                                                                              3   0.1         2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                            20  14  A     2    455 490                                                weeks                                                                         old)                                          102-B                                                                              97      3                  Pig (4                                                                            20  14  A     2    450 480                                                weeks                                                                         old)                                          102-C                                                                              97          3       2.5 × 10.sup.8 /100 g                                                          Pig (4                                                                            20  14  A     2    448 478                                                weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        40  97  3                      Pig (4                                                                            20  14  A     2    388 440                                                weeks                                                                         old)                                          Example                                                                       103  40  25  15  20             Pig (4                                                                            20  14  A     2    453 486                                                weeks                                                                         old)                                          104-A                                                                              60  25  15          2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                            20  14  A     2    451 483                                                weeks                                                                         old)                                          104-B                                                                              75      25          2.5 × 10.sup.10 /100 g                                                         Pig (4                                                                            20  14  A     2    448 478                                                weeks                                                                         old)                                          104-C                                                                              75      5   20             Pig (4                                                                            20  14  A     2    446 479                                                weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        41  75  25                     Pig (4                                                                            20  14  A     2    398 456                                                weeks                                                                         old)                                          Example                                                                       105  90  7.5 2.5                Calf (3                                                                           20  21  B     4    1029                                                                              1780                                               weeks                                                                         old)                                          106  91.25                                                                             7.5     1.25           Calf (3                                                                           20  21  B     4    1038                                                                              1769                                               weeks                                                                         old)                                          107  88.75                                                                             7.5 2.5 1.25           Calf (3                                                                           20  21  B     4    1043                                                                              1779                                               weeks                                                                         old)                                          108-A                                                                              90  7.5 2.5         2.5 × 10.sup.8 /100 g                                                          Calf (3                                                                           20  21  B     4    1029                                                                              1768                                               weeks                                                                         old)                                          108-B                                                                              92.5    7.5                Calf (3                                                                           20  21  B     4    1021                                                                              1760                                               weeks                                                                         old)                                          108-C                                                                              92.5        7.5     2.5 × 10.sup.8 /100 g                                                          Calf (3                                                                           20  21  B     4    1016                                                                              1758                                               weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        42  92.5                                                                              7.5                    Calf (3                                                                           20  21  B     4    880 1680                                               weeks                                                                         old)                                          Example                                                                       109  96.9                                                                              3   0.1                Calf (3                                                                           20  21  B     4    991 1769                                               weeks                                                                         old)                                          110  96.9                                                                              3       0.1            Calf (3                                                                           20  21  B     4    986 1756                                               weeks                                                                         old)                                          111  96.8                                                                              3   0.1 0.1            Calf (3                                                                           20  21  B     4    998 1768                                               weeks                                                                         old)                                          112-A                                                                              96.9                                                                              3   0.1         2.5 × 10.sup.8 /100 g                                                          Calf (3                                                                           20  21  B     4    976 1750                                               weeks                                                                         old)                                          112-B                                                                              97      3           2.5 × 10.sup.8 /100 g                                                          Calf (3                                                                           20  21  B     4    970 1740                                               weeks                                                                         old)                                          112-C                                                                              97          3              Calf (3                                                                           20  21  B     4    965 1743                                               weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        43  97  3                      Calf (3                                                                           20  21  B     4    898 1698                                               weeks                                                                         old)                                          Example                                                                       113  40  25  15  20             Calf (3                                                                           20  21  B     4    976 1763                                               weeks                                                                         old)                                          114-A                                                                              60  25  15          2.5 × 10.sup.10 /100 g                                                         Calf (3                                                                           20  21  B     4    981 1745                                               weeks                                                                         old)                                          114-B                                                                              75      25                 Calf (3                                                                           20  21  B     4    970 1748                                               weeks                                                                         old)                                          114-C                                                                              75      5   20      2.5 × 10.sup.10 /100 g                                                         Calf (3                                                                           20  21  B     4    972 1741                                               weeks                                                                         old)                                          Compar-                                                                       ative                                                                         Example                                                                        44  75  25                     Calf (3                                                                           20  21  B     4    887 1683                                               weeks                                                                         old)                                          __________________________________________________________________________     *Kind of Base Feed Stuff                                                      **Proportion of the pharmaceutical composition added to Base Feed Stuff       (wt. %)                                                                  

EXAMPLES 115-157 AND COMPARATIVE EXAMPLES 45-63

Components shown in Table 3 below were mixed in accordance with weightproportions shown in Table 3 to prepare pharmaceutical compositions foranimals of the present Examples 115-157 and Comparative Examples 45-63.

Each of the pharmaceutical composition for animals was added to BaseFeed Stuff C shown below at a given weight proportion shown in Table 3to prepare test feed stuffs. Each of the test feed stuff was fed toanimals freely. The results are shown in Table 3 below.

    ______________________________________                                        Composition of Base Feed Stuff C                                              ______________________________________                                        Corn              400 weight parts                                            Milo              230 weight parts                                            Soybean meal      270 weight parts                                            Fish powder (65%)  50 weight parts                                            Yellow grease      25 weight parts                                            Calcium carbonate  5 weight parts                                             Calcium orthophosphate                                                                           12 weight parts                                            Salt               1.5 weight parts                                           Premix vitamins & minerals                                                                       6.5 weight parts                                           ______________________________________                                    

                                      TABLE 3-(i)                                 __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)  Num-                                             Ci-    Powdery flesh                                                                         Lactobacillus                                                                        Kind   ber Feed                                         tric                                                                             Vine-                                                                             of Japanese                                                                           bifidus                                                                              of     of  periods   P.F.B.**                                                                           P.G.A.                    Sugar                                                                             acid                                                                             gar apricot (cells/100 g)                                                                        animal animals                                                                           (days)                                                                            K.B.F.S.*                                                                           (wt.                                                                               (%)                __________________________________________________________________________    Example                                                                       115    90  7.5                                                                              2.5                Chicken (15                                                                          5200                                                                              45  C     1    99.6                                                days old)                                    116    91.25                                                                             7.5    1.25           Chicken (15                                                                          5200                                                                              45  C     1    99.6                                                days old)                                    117    88.75                                                                             7.5                                                                              2.5 1.25           Chicken (15                                                                          5200                                                                              45  C     1    99.5                                                days old)                                    118-A  90  7.5                                                                              2.5         2.5 × 10.sup.8 /100 g                                                          Chicken (15                                                                          5200                                                                              45  C     1    99.4                                                days old)                                    118-B  92.5   7.5         2.5 × 10.sup. 8 /100 g                                                         Chicken (15                                                                          5200                                                                              45  C     1    99.2                                                days old)                                    118-C  92.5       7.5            Chicken (15                                                                          5200                                                                              45  C     1    99.1                                                days old)                                    Comparative                                                                   Example                                                                        45    92.5                                                                              7.5                   Chicken (15                                                                          5200                                                                              45  C     1    95.3                                                days old)                                    Example                                                                       119    96.9                                                                              3  0.1                Chicken (15                                                                          5200                                                                              45  C     1    98.7                                                days old)                                    120    96.9                                                                              3      0.1            Chicken (15                                                                          5200                                                                              45  C     1    98.8                                                days old)                                    121    96.8                                                                              3  0.1 0.1            Chicken (15                                                                          5200                                                                              45  C     1    99.1                                                days old)                                    122-A  96.9                                                                              3  0.1         2.5 × 10.sup.8 /100 g                                                          Chicken (15                                                                          5200                                                                              45  C     1    98.9                                                days old)                                    122-B  97     3                  Chicken (15                                                                          5200                                                                              45  C     1    98.7                                                days old)                                    122-C  97         3       2.5 × 10.sup.8 /100 g                                                          Chicken (15                                                                          5200                                                                              45  C     1    98.8                                                days old)                                    Comparative                                                                   Example                                                                        46    97  3                     Chicken (15                                                                          5200                                                                              45  C     1    96.9                                                days old)                                    Example                                                                       123    40  25 15  20             Chicken (15                                                                          5200                                                                              45  C     1    98.9                                                days old)                                    124-A  60  25 15          2.5 × 10.sup.10 /100 g                                                         Chicken (15                                                                          5200                                                                              45  C     1    98.8                                                days old)                                    124-B  75     25          2.5 × 10.sup.10 /100 g                                                         Chicken (15                                                                          5200                                                                              45  C     1    98.8                                                days old)                                    124-C  75     5   20             Chicken (15                                                                          5200                                                                              45  C     1    98.8                                                days old)                                    Comparative                                                                   Example                                                                        47    75  25                    Chicken (15                                                                          5200                                                                              45  C     1    96.8                                                days old)                                    Example                                                                       125    10  50 30  10             Chicken (15                                                                          2200                                                                              45  C     1    98.9                                                days old)                                    126    10  50 15  25             Chicken (15                                                                          2200                                                                              45  C     1    98.8                                                days old)                                    127-A  88  1  1   10             Chicken (15                                                                          2200                                                                              45  C     1    98.7                                                days old)                                    127-B  99     1                  Chicken (15                                                                          2200                                                                              45  C     1    98.7                                                days old)                                    127-C  99         1              Chicken (15                                                                          2200                                                                              45  C     1    98.6                                                days old)                                    Comparative                                                                   Example                                                                        48    10  90                    Chicken (15                                                                          2200                                                                              45  C     1    96.7                                                days old)                                     49    50  50                    Chicken (15                                                                          2200                                                                              45  C     1    96.6                                                days old)                                     50    99  1                     Chicken (15                                                                          2200                                                                              45  C     1    96.9                                                days old)                                    __________________________________________________________________________     *Kind of Base Feed Stuff                                                      **Proportion of the pharmaceutical composition added to Base Feed Stuff       (wt. %)                                                                  

                                      TABLE 3-(ii)                                __________________________________________________________________________           Mix proportions of each component in pharma-                                                                Num-                                            ceutical composition for animals (wt. %)                                                             Kind   ber Feed                                              Lactic     rind of                                                                             of     of  periods   P.F.B.**                          Glucose                                                                             acid Vinegar                                                                             lemon animal animals                                                                           (days)                                                                            K.B.F.S.*                                                                           (wt.                                                                               P.G.A.                __________________________________________________________________________                                                            (%)                   Example                                                                       128    10    50   30    10    Chicken (15                                                                          2200                                                                              45  C     1    98.7                                                days old)                                       129    10    50   15    25    Chicken (15                                                                          2200                                                                              45  C     1    98.9                                                days old)                                       130    88    1    1     10    Chicken (15                                                                          2200                                                                              45  C     1    98.6                                                days old)                                       131    98.9  1          0.1   Chicken (15                                                                          2200                                                                              45  C     1    98.8                                                days old)                                       132-A  88.75 7.5  2.5   1.25  Chicken (15                                                                          2200                                                                              45  C     1    99.4                                                days old)                                       132-B  99               1     Chicken (15                                                                          2200                                                                              45  C     1    98.7                                                days old)                                       132-C*.sup.8                                                                         99                     Chicken (15                                                                          2200                                                                              45  C     1    98.6                                                days old)                                       132-D  92.5                   Chicken (15                                                                          2200                                                                              45  C     1    98.7                                                days old)                                       132-E*.sup.9                                                                         92.5                   Chicken (15                                                                          2200                                                                              45  C     1    98.8                                                days old)                                       Comparative                                                                   Example                                                                        51    10    90               Chicken (15                                                                          2200                                                                              45  C     1    96.8                                                days old)                                        52    50    50               Chicken (15                                                                          2200                                                                              45  C     1    96.7                                                days old)                                        53    99    1                Chicken (15                                                                          2200                                                                              45  C     1    96.9                                                days old)                                        54    92.5  7.5              Chicken (15                                                                          2200                                                                              45  C     1    97.0                                                days old)                                       __________________________________________________________________________     *Kind of Base Feed Stuff                                                      **Proportion of the pharmaceutical composition added to Base Feed Stuff       (wt. %)                                                                       *.sup.8 In addition to 99 wt. % of glucose, 1 wt. % of powdery tomato is      mixed.                                                                        *.sup.9 In addition to 92.5 wt. % of glucose, 7.5 wt. % of powdery tomato     is mixed.                                                                

                                      TABLE 3-(iii)                               __________________________________________________________________________           Mix proportions of each component in pharma-                                  ceutical composition for animals (wt. %)                                                             Kind   Number                                                                             Feed                                             Fumaric    Powdery                                                                             of     of   periods   P.F.B.**                         Glucose                                                                             acid Vinegar                                                                             tomato                                                                              animal animals                                                                            (days)                                                                            K.B.F.S.*                                                                           (wt                                                                                P.G.A.               __________________________________________________________________________                                                             (%)                  Example                                                                       133    10    50   30    10    Chicken (15                                                                          2200 45  C     1    98.8                                               days old)                                       134    10    50   15    25    Chicken (15                                                                          2200 45  C     1    98.9                                               days old)                                       135    88    1    1     10    Chicken (15                                                                          2200 45  C     1    98.7                                               days old)                                       136    98.9  1          0.1   Chicken (15                                                                          2200 45  C     1    98.8                                               days old)                                       137    88.75 7.5  2.5   1.25  Chicken (15                                                                          2200 45  C     1    99.3                                               days old)                                       Comparative                                                                   Example                                                                        55    10    90               Chicken (15                                                                          2200 45  C     1    96.9                                               days old)                                        56    50    50               Chicken (15                                                                          2200 45  C     1    96.8                                               days old)                                        57    99    1                Chicken (15                                                                          2200 45  C     1    96.9                                               days old)                                       __________________________________________________________________________     *Kind of Base Feed Stuff                                                      **Proportion of the pharmaceutical composition added to Base Feed Stuff       (wt. %)                                                                  

                                      TABLE 3-(iv)                                __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)  Num-                                                      Powdery flesh                                                                         Lactobacillus                                                                        Kind ber Feed                                         Citric   of Japanese                                                                           bifidus                                                                              of   of  periods   P.F.B.**                                                                           P.G.A.                    Sugar                                                                             acid                                                                              Vinegar                                                                            apricot (cells/100 g)                                                                        animal                                                                             animals                                                                           (days)                                                                            K.B.F.S.*                                                                           (wt.                                                                               (%)                __________________________________________________________________________    Example                                                                       138    90  7.5 2.5                 Quail (20                                                                          500 40  C     1    98.4                                                  days old)                                  139    91.25                                                                             7.5      1.25           Quail (20                                                                          500 40  C     1    98.6                                                  days old)                                  140    88.75                                                                             7.5 2.5  1.25           Quail (20                                                                          500 40  C     1    98.8                                                  days old)                                  141-A  90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Quail (20                                                                          500 40  C     1    98.6                                                  days old)                                  141-B  92.5    7.5          2.5 × 10.sup. 8 /100 g                                                         Quail (20                                                                          500 40  C     1    98.4                                                  days old)                                  141-C  92.5         7.5            Quail (20                                                                          500 40  C     1    98.2                                                  days old)                                  Comparative                                                                   Example                                                                        58    92.5                                                                              7.5                     Quail (20                                                                          500 40  C     1    93.8                                                  days old)                                  Example                                                                       142    96.9                                                                              3   0.1                 Quail (20                                                                          500 40  C     1    97.4                                                  days old)                                  143    96.9                                                                              3        0.1            Quail (20                                                                          500 40  C     1    97.6                                                  days old)                                  144    96.8                                                                              3   0.1  0.1            Quail (20                                                                          500 40  C     1    98.0                                                  days old)                                  145-A  96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Quail (20                                                                          500 40  C     1    97.6                                                  days old)                                  145-B  97      3                   Quail (20                                                                          500 40  C     1    97.2                                                  days old)                                  145-C  97           3       2.5 × 10.sup.8 /100 g                                                          Quail (20                                                                          500 40  C     1    97.4                                                  days old)                                  Comparative                                                                   Example                                                                        59    97  3                       Quail (20                                                                          500 40  C     1    95.4                                                  days old)                                  Example                                                                       146    40  25  15   20             Quail (20                                                                          500 40  C     1    97.4                                                  days old)                                  147-A  60  25  15           2.5 × 10.sup.10 /100 g                                                         Quail (20                                                                          500 40  C     1    97.6                                                  days old)                                  147-B  75      25           2.5 × 10.sup.10 /100 g                                                         Quail (20                                                                          500 40  C     1    97.4                                                  days old)                                  147-C  75      5    20             Quail (20                                                                          500 40  C     1    97.2                                                  days old)                                  Comparative                                                                   Example                                                                        60    75  25                      Quail (20                                                                          500 40  C     1    95.2                                                  days old)                                  Example                                                                       148    90  7.5 2.5                 Turkey                                                                             500 40  C     1    98.8                                                  (20 days                                                                      old)                                       149    91.25                                                                             7.5      1.25           Turkey                                                                             500 40  C     1    99.0                                                  (20 days                                                                      old)                                       150    88.75                                                                             7.5 2.5  1.25           Turkey                                                                             500 40  C     1    98.8                                                  (20 days                                                                      old)                                       151-A  90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          Turkey                                                                             500 40  C     1    99.0                                                  (20 days                                                                      old)                                       151-B  92.5    7.5                 Turkey                                                                             500 40  C     1    98.6                                                  (20 days                                                                      old)                                       151-C  92.5         7.5     2.5 × 10.sup.8 /100 g                                                          Turkey                                                                             500 40  C     1    98.8                                                  (20 days                                                                      old)                                       Comparative                                                                   Example                                                                        61    92.5                                                                              7.5                     Turkey                                                                             500 40  C     1    89.4                                                  (20 days                                                                      old)                                       Example                                                                       152    96.9                                                                              3   0.1                 Turkey                                                                             500 40  C     1    97.4                                                  (20 days                                                                      old)                                       153    96.9                                                                              3        0.1            Turkey                                                                             500 40  C     1    97.6                                                  (20 days                                                                      old)                                       154    96.8                                                                              3   0.1  0.1            Turkey                                                                             500 40  C     1    97.4                                                  (20 days                                                                      old)                                       155-A  96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          Turkey                                                                             500 40  C     1    97.6                                                  (20 days                                                                      old)                                       155-B  97      3            2.5 × 10.sup.8 /100 g                                                          Turkey                                                                             500 40  C     1    97.2                                                  (20 days                                                                      old)                                       155-C  97           3              Turkey                                                                             500 40  C     1    97.0                                                  (20 days                                                                      old)                                       Comparative                                                                   Example                                                                        62    97  3                       Turkey                                                                             500 40  C     1    90.6                                                  (20 days                                                                      old)                                       Example                                                                       156    40  25  15   20             Turkey                                                                             500 40  C     1    97.8                                                  (20 days                                                                      old)                                       157-A  60  25  15           2.5 ×  10.sup.10 /100                                                          Turkey                                                                             500 40  C     1    98.0                                                  (20 days                                                                      old)                                       157-B  75      25                  Turkey                                                                             500 40  C     1    97.6                                                  (20 days                                                                      old)                                       157-C  75      5    20      2.5 × 10.sup.10 /100 g                                                         Turkey                                                                             500 40  C     1    97.4                                                  (20 days                                                                      old)                                       Comparative                                                                   Example                                                                        63    75  25                      Turkey                                                                             500 40  C     1    90.2                                                  (20 days                                                                      old)                                       __________________________________________________________________________     *Kind of Base Feed Stuff                                                      **Proportion of the pharmaceutical composition added to Base Feed Stuff       (wt. %)                                                                  

EXAMPLES 158-220 AND COMPARATIVE EXAMPLES 64-82

Components shown in Table 4 below were mixed in accordance with weightproportions shown in Table 4 to prepare pharmaceutical compositions foranimals of the present Examples 158-220 and Comparative Examples 64-82.1 g of each of the pharmaceutical compositions for animals was added to100 g of Base Feed Stuff D, E or F shown below to prepare test feedstuffs. Each of the test feed stuffs was fed to animals freely. "Growth%" is shown in Table 4 below.

    ______________________________________                                        Composition of Base Feed Stuff D                                              ______________________________________                                        Fish powder         69.4 weight parts                                         Beer yeast          2.0 weight parts                                          α-Starch      23.0 weight parts                                         Vitamins            3.6 weight parts                                          Minerals            2.0 weight parts                                          ______________________________________                                    

    ______________________________________                                        Composition of Base Feed Stuff E                                              ______________________________________                                        Fish powder         65.0 weight parts                                         Cod-liver oil       5.0 weight parts                                          Wheat flour         17.4 weight parts                                         Vitamins            4.0 weight parts                                          Minerals            5.0 weight parts                                          Carboxy methylcellulose (CMC)                                                                     5.0 weight parts                                          ______________________________________                                    

    ______________________________________                                        Composition of Base Feed Stuff F                                              ______________________________________                                        Fish powder         74.4 weight parts                                         Corn starch         6.0 weight parts                                          Cod-liver oil       10.0 weight parts                                         Vitamins            3.6 weight parts                                          Minerals            1.0 weight parts                                          CMC                 5.0 weight parts                                          ______________________________________                                    

                                      TABLE 4-(i)                                 __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)                                                   Cit-   Powdery flesh                                                                         Lactobacillus                                                                        Kind  Number                                                                             Feed      Feed per                           ric    of Japanese                                                                           bifidus                                                                              of    of   periods   day                            Sugar                                                                             acid                                                                             Vinegar                                                                           apricot (cells/100 g)                                                                        fish  fishes                                                                             (days)                                                                            K.B.F.S.*                                                                           (times)                                                                            P.G.A.             __________________________________________________________________________    Example                                                                       158    90  7.5                                                                              2.5                Eel   500  70  D     1    97.6                                                (30 g/fish)                                  159    91.25                                                                             7.5    1.25           Eel   500  70  D     1    97.8                                                (30 g/fish)                                  160    88.75                                                                             7.5                                                                              2.5 1.25           Eel   500  70  D     1    97.8                                                (30 g/fish)                                  161-A  90  7.5                                                                              2.5         2.5 × 10.sup.8 /100 g                                                          Eel   500  70  D     1    97.8                                                (30 g/fish)                                  161-B  92.5   7.5         2.5 × 10.sup.8 /100 g                                                          Eel   500  70  D     1    97.4                                                (30 g/fish)                                  161-C  92.5       7.5            Eel   500  70  D     1    97.6                                                (30 g/fish)                                  Comparative                                                                   Example                                                                        64    92.5                                                                              7.5                   Eel   500  70  D     1    82.0                                                (30 g/fish)                                  Example                                                                       162    96.9                                                                              3  0.1                Eel   500  70  D     1    95.0                                                (30 g/fish)                                  163    96.9                                                                              3      0.1            Eel   500  70  D     1    95.4                                                (30 g/fish)                                  164    96.8                                                                              3  0.1 0.1            Eel   500  70  D     1    95.4                                                (30 g/fish)                                  165-A  96.9                                                                              3  0.1         2.5 × 10.sup.8 /100 g                                                          Eel   500  70  D     1    95.8                                                (30 g/fish)                                  165-B  97     3                  Eel   500  70  D     1    95.0                                                (30 g/fish)                                  165-C  97         3       2.5 × 10.sup.8 /100 g                                                          Eel   500  70  D     1    95.2                                                (30 g/fish)                                  Comparative                                                                   Example                                                                        65    97  3                     Eel   500  70  D     1    83.6                                                (30 g/fish)                                  Example                                                                       166    40  25 15  20             Eel   500  70  D     1    96.8                                                (30 g/fish)                                  167-A  60  25 15          2.5 × 10.sup.10 /100 g                                                         Eel   500  70  D     1    96.8                                                (30 g/fish)                                  167-B  75     25          2.5 × 10.sup.10 /100 g                                                         Eel   500  70  D     1    96.2                                                (30 g/fish)                                  167-C  75     5   20             Eel   500  70  D     1    96.4                                                (30 g/fish)                                  Comparative                                                                   Example                                                                        66    75  25                    Eel   500  70  D     1    83.2                                                (30 g/fish)                                  Example                                                                       168    10  50 30  10             Eel   500  70  D     1    94.0                                                (30 g/fish)                                  169    10  50 15  25             Eel   500  70  D     1    93.6                                                (30 g/fish)                                  170-A  88  1  1   10             Eel   500  70  D     1    93.8                                                (30 g/fish)                                  170-B  99     1                  Eel   500  70  D     1    93.0                                                (30 g/fish)                                  170-C  99         1              Eel   500  70  D     1    93.2                                                (30 g/fish)                                  Comparative                                                                   Example                                                                        67    10  90                    Eel   500  70  D     1    88.6                                                (30 g/fish)                                   68    50  50                    Eel   500  70  D     1    87.8                                                (30 g/fish)                                   69    99  1                     Eel   500  70  D     1    88.4                                                (30 g/fish)                                  __________________________________________________________________________     *Kind of Base Feed Stuff                                                 

                                      TABLE 4-(ii)                                __________________________________________________________________________           Mix proportions of each component in pharma-                                  ceutical composition for animals (wt. %)                                                       Powdery                                                                             Kind  Number                                                                             Feed       Feed per                               Lactic     rind of                                                                             of    of   periods    day                              Glucose                                                                             acid Vinegar                                                                             lemon fish  fishes                                                                             (days)                                                                             K.B.F.S.*                                                                           (times)                                                                            P.G.A.               __________________________________________________________________________                                                             (%)                  Example                                                                       171    10    50   30    10    Eel   500  70   D     1    94.2                                               (30 g/fish)                                     172    10    50   15    25    Eel   500  70   D     1    96.2                                               (30 g/fish)                                     173    88    1    1     10    Eel   500  70   D     1    95.6                                               (30 g/fish)                                     174    98.9  1          0.1   Eel   500  70   D     1    93.8                                               (30 g/fish)                                     175-A  88.75 7.5  2.5   1.25  Eel   500  70   D     1    97.6                                               (30 g/fish)                                     175-B  99               1     Eel   500  70   D     1    93.8                                               (30 g/fish)                                     175-C*.sup.10                                                                        99                     Eel   500  70   D     1    93.6                                               (30 g/fish)                                     175-D  92.5             7.5   Eel   500  70   D     1    94.2                                               (30 g/fish)                                     175-E*.sup.11                                                                        92.5                   Eel   500  70   D     1    94.0                                               (30 g/fish)                                     Comparative                                                                   Example                                                                        70    10    90               Eel   500  70   D     1    88.6                                               (30 g/fish)                                      71    50    50               Eel   500  70   D     1    88.0                                               (30 g/fish)                                      72    99    1                Eel   500  70   D     1    87.0                                               (30 g/fish)                                      73    92.5  7.5              Eel   500  70   D     1    88.4                                               (30 g/fish)                                     __________________________________________________________________________     *Kind of Base Feed Stuff                                                      *.sup.10 In addition to 99 wt. % of glucose, 1 wt. % of powdery tomato is     mixed.                                                                        *.sup.11 In addition to 92.5 wt. % of glucose, 7.5 wt. % of powdery tomat     is mixed.                                                                

                                      TABLE 4-(iii)                               __________________________________________________________________________           Mix proportions of each component in pharma-                                  ceutical composition for animals (wt. %)                                                              Kind  Number                                                                             Feed      Feed per                               Fumaric     Powdery                                                                             of    of   periods   day                              Glucose                                                                             acid  Vinegar                                                                             tomato                                                                              fish  fishes                                                                             (days)                                                                            K.B.F.S.*                                                                           (times)                                                                            P.G.A.               __________________________________________________________________________                                                             (%)                  Example                                                                       176    10    50    30    10    Eel   500  70  D     1    94.4                                                (30 g/fish)                                    177    10    50    15    25    Eel   500  70  D     1    93.8                                                (30 g/fish)                                    178    88    1     1     10    Eel   500  70  D     1    94.2                                                (30 g/fish)                                    179    98.9  1           0.1   Eel   500  70  D     1    94.0                                                (30 g/fish)                                    180    88.75 7.5   2.5   1.25  Eel   500  70  D     1    96.8                                                (30 g/fish)                                    Comparative                                                                   Example                                                                        74    10    90                Eel   500  70  D     1    87.4                                                (30 g/fish)                                     75    50    50                Eel   500  70  D     1    88.8                                                (30 g/fish)                                     76    99    1                 Eel   500  70  D     1    86.2                                                (30 g/fish)                                    __________________________________________________________________________     *Kind of Base Feed Stuff                                                 

                                      TABLE 4-(iv)                                __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)   Num-          Feed                              Cit-   Powdery flesh                                                                         Lactobiacillus                                                                       Kind    ber Feed      per                               ric                                                                              Vine-                                                                             of Japanese                                                                           bifidus                                                                              of      of  periods   day                           Sugar                                                                             acid                                                                             gar apricot (cells/100 g)                                                                        fish    fishes                                                                            (days)                                                                            K.B.F.S.*                                                                           (times)                                                                           P.G.A.             __________________________________________________________________________    Example                                                                       181    90  7.5                                                                              2.5                Horse mackerel                                                                        200 140 E     4   97.0                                                (40 g/fish)                                  182    91.25                                                                             7.5    1.25           Horse mackerel                                                                        200 140 E     4   97.0                                                (40 g/fish)                                  183    88.75                                                                             7.5                                                                              2.5 1.25           Horse mackerel                                                                        200 140 E     4   98.5                                                (40 g/fish)                                  184-A  90  7.5                                                                              2.5         2.5 × 10.sup.8 /100 g                                                          Horse mackerel                                                                        200 140 E     4   97.0                                                (40 g/fish)                                  184-B  92.5   7.5         2.5 × 10.sup.8 /100 g                                                          Horse mackerel                                                                        200 140 E     4   96.5                                                (40 g/fish)                                  184-C  92.5       7.5            Horse mackerel                                                                        200 140 E     4   96.0                                                (40 g/fish)                                  Comparative                                                                   Example                                                                        77    92.5                                                                              7.5                   Horse mackerel                                                                        200 140 E     4   78.5                                                (40 g/fish)                                  Example                                                                       185    96.9                                                                              3  0.1                Horse mackerel                                                                        200 140 E     4   93.5                                                (40 g/fish)                                  186    96.9                                                                              3      0.1            Horse mackerel                                                                        200 140 E     4   93.5                                                (40 g/fish)                                  187    96.8                                                                              3  0.1 0.1            Horse mackerel                                                                        200 140 E     4   94.0                                                (40 g/fish)                                  188-A  96.9                                                                              3  0.1         2.5 × 10.sup.8 /100 g                                                          Horse mackerel                                                                        200 140 E     4   94.0                                                (40 g/fish)                                  188-B  97     3                  Horse mackerel                                                                        200 140 E     4   93.0                                                (40 g/fish)                                  188-C  97         3       2.5 × 10.sup.8 /100 g                                                          Horse mackerel                                                                        200 140 E     4   92.5                                                (40 g/fish)                                  Comparative                                                                   Example                                                                        78    97  3                     Horse mackerel                                                                        200 140 E     4   81.5                                                (40 g/fish)                                  Example                                                                       189    40  25 15  20             Horse mackerel                                                                        200 140 E     4   96.5                                                (40 g/fish)                                  190-A  60  25 15                 Horse mackerel                                                                        200 140 E     4   96.0                                                (40 g/fish)                                  190-B  75     25          2.5 × 10.sup.10 /100 g                                                         Horse mackerel                                                                        200 140 E     4   95.5                                                (40 g/fish)                                  190-C  75     5   20             Horse mackerel                                                                        200 140 E     4   95.0                                                (40 g/fish)                                  Comparative                                                                   Example                                                                        79    75  25                    Horse mackerel                                                                        200 140 E     4   80.0                                                (40 g/fish)                                  Example                                                                       191    90  7.5                                                                              2.5                Yellowtail                                                                            200 350 F     4   97.5                                                (20 g/fish)                                  192    91.25                                                                             7.5    1.25           Yellowtail                                                                            200 350 F     4   97.0                                                (20 g/fish)                                  193    88.75                                                                             7.5                                                                              2.5 1.25           Yellowtail                                                                            200 350 F     4   97.5                                                (20 g/fish)                                  194-A  90  7.5                                                                              2.5         2.5 × 10.sup.8 /100 g                                                          Yellowtail                                                                            200 350 F     4   97.0                                                (20 g/fish)                                  194-B  92.5   7.5                Yellowtail                                                                            200 350 F     4   96.0                                                (20 g/fish)                                  194-C  92.5       7.5     2.5 × 10.sup.8 /100 g                                                          Yellowtail                                                                            200 350 F     4   96.5                                                (20 g/fish)                                  Comparative                                                                   Example                                                                        80    92.5                                                                              7.5                   Yellowtail                                                                            200 350 F     4   85.0                                                (20 g/fish)                                  Example                                                                       195    96.9                                                                              3  0.1                Yellowtail                                                                            200 350 F     4   95.0                                                (20 g/fish)                                  196    96.9                                                                              3      0.1            Yellowtail                                                                            200 350 F     4   94.5                                                (20 g/fish)                                  197    96.8                                                                              3  0.1 0.1            Yellowtail                                                                            200 350 F     4   95.0                                                (20 g/fish)                                  198-A  96.9                                                                              3  0.1         2.5 × 10.sup.8 /100 g                                                          Yellowtail                                                                            200 350 F     4   95.0                                                (20 g/fish)                                  198-B  97     3           2.5 × 10.sup.8 /100 g                                                          Yellowtail                                                                            200 350 F     4   93.5                                                (20 g/fish)                                  198-C  97         3              Yellowtail                                                                            200 350 F     4   94.0                                                (20 g/fish)                                  Comparative                                                                   Example                                                                        81    97  3                     Yellowtail                                                                            200 350 F     4   87.0                                                (20 g/fish)                                  Example                                                                       199    40  25 15  20             Yellowtail                                                                            200 350 F     4   97.0                                                (20 g/fish)                                  200-A  60  25 15          2.5 × 10.sup.10 /100 g                                                         Yellowtail                                                                            200 350 F     4   96.0                                                (20 g/fish)                                  200-B  75     25                 Yellowtail                                                                            200 350 F     4   96.0                                                (20 g/fish)                                  200-C  75     5   20      2.5 × 10.sup.10 /100 g                                                         Yellowtail                                                                            200 350 F     4   95.5                                                (20 g/fish)                                  Comparative                                                                   Example                                                                        82    75  25                    Yellowtail                                                                            200 350 F     4   86.5                                                (20 g/fish)                                  __________________________________________________________________________     *Kind of Base Feed Stuff                                                 

EXAMPLES 201-210 AND COMPARATIVE EXAMPLES 83-85

Components shown in Table 5 below were mixed in accordance with weightproportions shown in Table 5 to prepare pharmaceutical compositions foranimals of the present Examples 201-210 and Comparative Examples 83-85.0.5 g of each of the pharmaceutical compositions were added to 100 g ofBase Feed Stuff G shown below to prepare test feed stuffs. Each of thetest feed stuffs was fed freely to milk cows of one month old for 60days. The amount of milk obtained was determined every day and the meanmilk fat was determined every ten days. The results are shown in Table 5below.

    ______________________________________                                        Composition of Base Feed Stuff G                                              ______________________________________                                        Corn            40.0 weight parts                                             Milo            13.5 weight parts                                             Wheat flour     18.0 weight parts                                             Barley          6.5 weight parts                                              Wheat bran      9.0 weight parts                                              Soybean oil meal                                                                              7.0 weight parts                                              Molasses        2.7 weight parts                                              Calcium carbonate                                                                             1.5 weight parts                                              Calcium phosphate                                                                             1.1 weight parts                                              Salt            0.5 weight parts                                              Vitamins        0.1 weight parts                                              Minerals        0.1 weight parts                                              ______________________________________                                    

                                      TABLE 5                                     __________________________________________________________________________           Mix proportions of each component in pharmaceutical                           composition for animals (wt. %)                                                            Powdery flesh                                                                         Lactobacillus                                                Citric   of Japanese                                                                           bifidus                                                                              Amount of milk/                                   Sugar                                                                             acid                                                                              Vinegar                                                                            apricot (cells/100 g)                                                                        day. cow (kg)                                                                          M.M.F. (%)                        __________________________________________________________________________    Example                                                                       201    90  7.5 2.5                 23.3     3.8                               202    91.25                                                                             7.5      1.25           23.6     3.8                               203    88.75                                                                             7.5 2.5  1.25           24.6     3.8                               204-A  90  7.5 2.5          2.5 × 10.sup.8 /100 g                                                          24.0     3.8                               204-B  92.5    7.5                 23.0     3.8                               204-C  92.5         7.5            22.9     3.8                               Comparative                                                                   Example                                                                        83    92.5                                                                              7.5                     17.9     3.4                               Example                                                                       205    96.9                                                                              3   0.1                 22.0     3.7                               206    96.9                                                                              3        0.1            22.4     3.8                               207    96.8                                                                              3   0.1  0.1            23.3     3.7                               208-A  96.9                                                                              3   0.1          2.5 × 10.sup.8 /100 g                                                          23.0     3.7                               208-B  97      3                   21.8     3.7                               208-C  97           3              21.5     3.7                               Comparative                                                                   Example                                                                         84   97  3                       18.2     3.4                               Example                                                                       209    40  25  15   20             21.8     3.7                               210-A  60  25  15           2.5 × 10.sup.10 /100 g                                                         22.3     3.7                               210-B  75      25                  21.0     3.7                               210-C  75      5    20             22.0     3.7                               Comparative                                                                   Example                                                                        85    75  25                      18.4     3.4                               __________________________________________________________________________

EXAMPLE 211

88.75 weight parts of sugar, 7.5 weight parts of citric acid, 2.5 weightparts of vinegar and 1.25 weight parts of powdery flesh of Japaneseapricot were mixed to prepare a pharmaceutical composition for broilers.0.7 g of the pharmaceutical composition was added to 100 g of Base FeedStuff H shown below, and the mixture was then fed freely to 2500 headsof broilers from 15 to 8 days before their forwarding.

Then, 1.28 g of said pharmaceutical composition was added to 100 g ofsaid Base Feed Stuff H, and fed freely to said 2500 heads of broilersduring 7 days before their forwarding.

    ______________________________________                                        Composition of Base Feed Stuff H                                              ______________________________________                                        Corn              450 weight parts                                            Milo              260 weight parts                                            Soybean meal      190 weight parts                                            Fish powder        50 weight parts                                            Yellow grease      30 weight parts                                            Calcium carbonate  7 weight parts                                             Calcium triphosphate                                                                             6 weight parts                                             Salt                                                                          Premix vitamins & minerals                                                                       5 weight parts                                             ______________________________________                                    

Said broilers were butchered and the quality of their bodies and meatswas observed, and the yield of meats was determined. On the other hand,said Base Feed Stuff H not containing the pharmaceutical composition ofthe present invention was feed to other 2500 broilers in the same manneras above. These broilers were butchered, and the quality of their bodiesand meats was also observed and the yield was determined.

The results are as follows:

Bodies of butchered broilers bred with the pharmaceutical composition ofthe present invention (called hereinafter "present broilers") had betterskin color and had tighter bodies than those of the comparativebroilers.

The yield of butchered broilers' bodies of the present broilers was 1.5%larger than that of the comparative broilers.

The thigh and breast of the present broilers had a beautiful pinkishcolor and were less fatty and were more resilient than those of thecomparative broilers. The stomachs of the present broilers were lessfatty.

The total weight of the fatty livers of the present 1200 broilers was1.6 kg, and this was one third of that of 1200 comparative broilers. Theyield of dissectioned bodies, which were dissectioned according to IVtype-dissection of Japanese Agriculture Standard, was 40.0% in case ofthe present broilers. On the other hand, in case of the comparativebroilers, that was 37.6%.

Breasts of the broilers were frozen in the temperature range of -3° C.to -8° C. for 81 hours, and then were thawed. Breasts of the presentbroilers were not hard. On the other hand, those of the comparativebroilers were hard. Then, these thawed breasts were maintained at 16° C.for 20 minutes. The breasts of the present broilers had less drips thanthose of the comparative broilers.

EXAMPLE 212

In this example, the pharmaceutical composition for broilers prepared inthe above Example 211 was used for beef cattles.

The pharmaceutical composition was fed to beef cattles of 490 days old36 g per beef cattle per day together with the Base Feed Stuff I shownbelow.

    ______________________________________                                        Base Feed Stuff I                                                             ______________________________________                                        Corn            40.0 weight parts                                             Milo            13.5 weight parts                                             Wheat flour     18.0 weight parts                                             Barley          6.5 weight parts                                              Wheat bran      9.0 weight parts                                              Soybean oil meal                                                                              7.0 weight parts                                              Molasses        2.7 weight parts                                              Calcium carbonate                                                                             1.5 weight parts                                              Calcium phosphate                                                                             1.1 weight parts                                              Salt            0.5 weight parts                                              Vitamins        0.1 weight parts                                              Minerals        0.1 weight parts                                              ______________________________________                                    

The beef cattles were butchered and dissectioned, and then the qualityof the beef was observed. The beef of the present beef cattles hadclearer red color than the comparative beef cattles. In the beef of thepresent beef cattles, fats were contained in dense and marble-likestates.

What we claim is:
 1. A process for preventing diarrhea in animals, whichcomprises:administering to an animal an anti-diarrheal effective amountof a veterinary composition comprising:(A) from about 0.1-50%, byweight, of at least one material selected form the group consisting of avinegar, selected from the group consisting of rice vinegar, maltvinegar, alcohol vinegar, cider vinegar and wine vinegar, a dried powderof the flesh of Japanese apricot excluding its kernel, a dried powder oforanges, a dried powder of tomatoes and a dried powder of strawberries,and (B) from about 99.9-50%, by weight, of(i) saccharides alone or acombination of saccharides and an edible organic acid selected form thegroup consisting of citric acid, fumaric acid, formic acid, succinicacid, tartaric acid, and lactic acid.
 2. The process of claim 1 wherein(A) in the veterinary composition is a mixture of a vinegar and thedried powder of the flesh of Japanese apricot.
 3. The process of claim 1wherein (A) in the veterinary composition is a vinegar.
 4. The processof claim 1 wherein (A) is the dried powder of the flesh of Japaneseapricot.
 5. The process of claim 1 wherein (B) in the veterinarycomposition are saccharides.
 6. The process of claim 1 wherein (B) inthe veterinary composition is the combination of saccharides and anedible organic acid.
 7. The process of claim 1 wherein the edibleorganic acid in the veterinary composition is at least one selected fromthe group consisting of citric acid, malic acid, fumaric acid, formicacid, succinic acid, tartaric acid and lactic acid.
 8. The process ofclaim 1 wherein (A) in the veterinary composition is about 0.1-50 wt. %and (B) in the veterinary composition is about 99.9-50 wt. %.
 9. Theprocess of claim 1 wherein the veterinary composition comprises 1-25% ofa vinegar, 1-20% of the dried powder of the flesh of Japanese apricot,15-95.5% of saccharide and 2.5-40% of the edible organic acid based onthe total weight of the composition.
 10. The process of claim 1 whereinthe veterinary composition comprises 1-25% of a vinegar and 75-99% ofsaccharides based on the total weight of the composition.
 11. Theprocess of claim 1 wherein the veterinary composition comprises 1-20% ofthe dried powder of the flesh of the Japanese apricot and 80-99% of thesaccharides based on the total weight of the composition.
 12. Theprocess of claim 1 wherein the veterinary composition comprises 1-25% ofa vinegar, 1-20% of the dried powder of the flesh of the Japaneseapricot and 55-98% of saccharides based on the total weight of thecomposition.
 13. A process for preventing diarrhea in animals, whichcomprises:administering to an animal an anti-diarrheal effective amountof a veterinary composition comprising: (A) from about 0.1-50%, byweight, of at least one material selected form the group consisting of avinegar, selected from the group consisting of rice vinegar, maltvinegar, alcohol vinegar, cider vinegar and wine vinegar, a dried powderof the flesh of Japanese apricot excluding its kernel, a dried powder oforanges, a dried powder of tomatoes and a dried powder of strawberries,and (B) from about 99.9-50%, by weight, of saccharides alone or incombination with an edible organic acid selected from the groupconsisting of citric acid, fumaric acid, formic acid, succinic acid,tartaric acid and lactic acid, in combination with a base feedstuff.